Abcam, ab315970, Anti-Noradrenaline antibody [EPR24435-114] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Noradrenaline antibody. Carrier free. Suitable for WB, ICC/IF, I-ELISA and reacts with Chemical samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24435-114,
Isotype:IgG,
Carrier free:Yes,
Applications:ICC/IF, WB, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab315970 is the carrier-free version of
ab315969
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Noradrenaline also known as norepinephrine is a neurotransmitter and hormone with a molecular weight of approximately 169.18 g/mol. It is primarily synthesized and released by neurons in the central nervous system and sympathetic nervous system from the adrenal medulla. Noradrenaline functions mechanically by acting on adrenergic receptors including alpha and beta subtypes which are distributed widely in the body. These receptors facilitate its major roles in various physiological responses such as modulation of heart rate focus and alertness.
Biological function summary
Noradrenaline plays significant roles in the fight-or-flight response and regulation of mood and blood pressure. As part of the catecholamine family noradrenaline often works in conjunction with other neurotransmitters like dopamine. It is involved in the formation of synaptic networks and influences neuronal signaling through its action on adrenergic receptors located in multiple tissues including the heart vasculature and brain. It does not form part of a molecular complex but interacts dynamically with several proteins that mediate its effects.
Pathways
Noradrenaline participates in the adrenergic signaling pathway influencing cardiovascular and metabolic processes. Within this pathway it regulates functions by interacting with proteins such as adrenergic receptors and modulates the release of neurotransmitters like serotonin. Additionally the stress response pathway also known as the hypothalamic-pituitary-adrenal axis significantly involves noradrenaline to regulate stress-related hormone synthesis and secretion affecting various bodily systems.
Noradrenaline shows connections to cardiovascular disorders and mood disorders such as depression. Abnormal noradrenaline levels can lead to hypertension by increasing peripheral vascular resistance alongside the involvement of proteins like beta-adrenergic receptors. In mood disorders dysregulation of noradrenaline along with dopamine and serotonin contributes to the pathophysiology of depression highlighting the complex neurochemical interactions affecting mental health.