Abcam, ab317013, Anti-Gata6 antibody [EPR25279-42] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal GATA6 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25279-42,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab317013 is the carrirer-free version of
ab317012
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GATA6 also known as GATA-binding protein 6 functions mechanically as a transcription factor in the GATA family. It has a molecular mass of approximately 60 kDa. GATA6 binds to the DNA sequence "GATA" present in the promoters of target genes regulating gene expression. This protein is expressed widely but is particularly noted in endodermal-derived tissues and plays a significant role in cellular differentiation and organogenesis during development.
Biological function summary
GATA6 plays an important role in endodermal lineage specification and development. It participates in complex networks regulating the differentiation and function of various organs such as the lungs heart and gut. This transcription factor interacts with other proteins in intricate transcriptional complexes to modulate the expression of genes involved in cell growth and development. GATA6 aids tissue-specific gene regulation facilitating organ development and function.
Pathways
GATA6 is integral to at least the TGF-beta signaling pathway and the Wnt signaling pathway. In these pathways GATA6 regulates the expression of genes that are essential for cell proliferation differentiation and apoptosis. It works closely with other key proteins like SMAD and β-catenin to drive downstream genetic programs that underpin cellular development and tissue homeostasis.
GATA6 mutations have been associated with congenital heart defects and pancreatic agenesis. Alterations in GATA6 function can disrupt its interaction with proteins such as NKX2-5 leading to developmental anomalies in the cardiovascular system. Similarly its dysregulation links to improper pancreatic development contributing to diabetes-related conditions. GATA6's dysfunction in these areas highlights its significance in developmental biology and disease pathology.