Abcam, ab317133, Anti-Dengue virus Envelope protein antibody [HL2089]

Size: 100µL
Rabbit Monoclonal POLG antibody. Suitable for WB and reacts with Transfected cell lysate, Dengue virus 4, Dengue virus 2 samples. Immunogen corresponding to Recombinant Fragment Protein within Dengue virus 2 Thailand/16681/84 Dengue virus Envelope protein.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2089,
Isotype:IgG,
Carrier free:No,
Reacts with:Dengue virus 2, Dengue virus 4,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Dengue virus 2 Thailand/16681/84 Dengue virus Envelope protein.P29990

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Dengue virus Envelope (E) protein plays an important role in the viral life cycle by facilitating viral entry into host cells. It is sometimes referred to as the Dengue E glycoprotein. The molecular mass of this protein is approximately 53 kilodaltons. The protein is expressed on the viral surface and is involved in the initial attachment of the virus to the target cell. This process is essential for the fusion of the viral and host cell membranes allowing the viral RNA to enter the host cell.
Biological function summary
The Dengue virus E protein is essential for viral infectivity and immune response modulation. The E protein forms a homodimer complex on the virus surface enabling it to interact with host cell receptors. This interaction leads to the endocytosis of the virus particle a mechanism that is critical for successful infection. It also participates in processes that help the virus evade the host immune system contributing to the persistence of the infection within the host.
Pathways
The Dengue virus E protein is heavily involved in the endocytosis pathway which is critical for the internalization of the virus into host cells. It is closely associated with proteins involved in pH-dependent fusion pathways. The E protein's conformational change under acidic conditions within the endosome enables the fusion of the viral and endosomal membranes. This process is interlinked with protein interactions in the cellular machinery that lead to the release of viral RNA into the cytoplasm.
The Dengue virus E protein is directly linked to dengue fever and related conditions such as dengue hemorrhagic fever (DHF). It is one of the main targets for neutralizing antibodies that the immune system produces during infection. The E protein's structure and sequence variations influence the severity of the disease and the host's immune response. This protein's interaction with host factors can complicate disease progression and is a target for vaccine development and therapeutic interventions.