Abcam, ab317142, Anti-Pepsinogen I antibody [HL2137]

Size: 100µL
Rabbit Monoclonal PEPA3 antibody. Suitable for IHC-P, ICC/IF, I-ELISA, WB and reacts with Human, Mouse, Rat, Recombinant full length protein - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2137,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, ICC/IF, I-ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pepsinogen I often referred to simply as pepsinogen is a zymogen form of the digestive enzyme pepsin. It possesses a molecular mass of approximately 44 kDa. This inactive precursor is synthesized and secreted by the gastric chief cells located in the stomach lining. Once released into the gastric lumen pepsinogen undergoes conversion into the active enzyme pepsin when exposed to the acidic pH of the stomach which facilitates protein breakdown during digestion.
Biological function summary
Pepsinogen I serves as an important component in the proteolytic process within the digestive system. It is not a part of a larger protein complex but functions independently after its activation. The conversion to pepsin enables the digestion of dietary proteins into smaller peptides and amino acids which are essential for the absorption and utilization by the body. This activity is fundamental to maintaining efficient nutrient processing and absorption in the gastrointestinal tract.
Pathways
The digestive process involving pepsinogen I is closely tied to the gastric acid secretion pathway. The enzyme pepsin derived from pepsinogen plays an important role in this pathway by breaking down proteins within the acidic environment of the stomach. Additionally pepsinogen activation indirectly interacts with other enzymes like gastric lipase which aids in the digestion of fats highlighting the interconnectedness of digestive pathways that ensure the body efficiently utilizes nutrients.
Pepsinogen I levels may be associated with conditions like gastritis and peptic ulcer disease. Aberrant expression or secretion can serve as a marker for these gastric disorders where pepsinogen I through its converted form pepsin can be involved in the excessive breakdown of the stomach lining. Additionally its relationship with gastric-related proteins like mucins which protect against acidic damage further accentuates its significance in maintaining gastric health and the potential implications when balance is disrupted.