Abcam, ab317170, Anti-PKC gamma antibody [HL2226]

Size: 100µL
Rabbit Monoclonal KPCG antibody. Suitable for IHC-P, WB and reacts with Rat, Human, Mouse, Recombinant full length protein samples. Immunogen corresponding to Recombinant Fragment Protein within Human PRKCG.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2226,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PRKCG.P05129

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein kinase C gamma (PKC gamma) also known as PKCγ is a member of the protein kinase C (PKC) family. This protein has a molecular weight of approximately 78 kDa. Expressed mainly in the central nervous system PKC gamma participates in various signaling pathways. It exists as a serine/threonine kinase and plays a fundamental role in modulating cellular functions in neurons.
Biological function summary
PKC gamma acts in the regulation of neuronal signaling processes and is a component of the synaptic transmission machinery. It associates with other proteins to form complex structures that influence physiological processes. PKC gamma contributes significantly to the functions of the central nervous system by modulating synaptic plasticity which is essential for learning and memory.
Pathways
PKC gamma participates in the MAPK and PI3K signaling pathways which are critical in cell growth and survival. The protein interacts with other PKC isozymes and signaling molecules within these pathways playing a role in phosphorylating specific target proteins. These interactions facilitate the regulation of cell cycle progression and apoptosis indicating its importance in cellular homeostasis.
Abnormal PKC gamma activity associates with spinocerebellar ataxia type 14 and addiction-related behavior. Spinocerebellar ataxia results from mutations affecting PKC gamma which disrupts its normal function and leads to neurodegeneration. Additionally PKC gamma’s interaction with other proteins such as GABAA receptors in addiction highlights potential therapeutic targets for treatment.