Abcam, ab317172, Anti-MLK4 antibody [HL2234]

Size: 100µL
Rabbit Monoclonal MLK4 antibody. Suitable for ICC/IF, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MAP3K21.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2234,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAP3K21.Q5TCX8

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MLK4 also known as Mixed Lineage Kinase 4 is a signaling protein involved in various cellular processes. It is a member of the MAP3K family and has a molecular weight of approximately 88 kDa. MLK4 is expressed in several tissues including the brain liver and kidney suggesting it plays roles in diverse physiological contexts. As a kinase it participates in phosphorylating specific substrates which impacts downstream signaling pathways.
Biological function summary
MLK4 influences cell proliferation differentiation and apoptosis through its kinase activity. It is part of signaling complexes that coordinate cellular responses to external stimuli linking surface receptors to the intracellular machinery. Through these roles MLK4 exerts important effects on cellular dynamics and maintenance of normal physiological balance.
Pathways
MLK4 integrates into the JNK and p38 MAPK signaling cascades which mediate responses to stress stimuli and regulate gene expression. MLK4 interacts with various other proteins including MLK3 to modulate these pathways effectively. Furthermore its role in these pathways positions MLK4 as an important player in ensuring cells react appropriately to potential damage or stress signals.
MLK4 has been associated with certain cancers and neurodegenerative diseases. Its involvement in cancer relates to its ability to influence cell growth and survival where MLK4 mutations or dysregulation might promote tumorigenesis. Moreover altered MLK4 signaling has links to Parkinson's disease particularly in conjunction with other kinases like LRRK2 suggesting its potential as a therapeutic target for modulating disease progression.