Abcam, ab317210, Anti-HEY1 antibody [HL2367]

Size: 100µL
Rabbit Monoclonal HEY1 antibody. Suitable for WB, IHC-P and reacts with Transfected cell lysate, Human, Rat, Zebrafish, Dog, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human HEY1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2367,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat, Dog, Zebrafish,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HEY1.Q9Y5J3

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HEY1 protein also known as Hes-related family bHLH transcription factor with YRPW motif 1 plays a significant role as a transcriptional repressor. It weighs approximately 33 kilodaltons. HEY1 is part of the hairy and enhancer of split family of proteins. Expression of HEY1 occurs in various tissues including the heart brain and liver. Within cells HEY1 localizes to the nucleus where it modulates gene expression by binding to specific DNA sequences.
Biological function summary
HEY1 functions as an important regulator of developmental processes. It participates in the Notch signaling pathway and regulates the transcription of genes involved in cell fate decisions. HEY1 forms a part of transcriptional complexes often associating with other proteins to modulate expression patterns important for differentiation and proliferation. These complexes enable it to exert control over target gene expression influencing processes like angiogenesis and myogenesis.
Pathways
HEY1 is prominently involved in the Notch signaling and Wnt pathways. Notch signaling regulates cell communication important for cell differentiation while the Wnt pathway influences cell growth and development. In both pathways HEY1 modulates signal transduction by interacting with proteins like RBPJ in the Notch pathway. HEY1's role in these pathways reveals its importance in maintaining cellular architecture and instructive developmental cues.
HEY1 is associated with various cancers and cardiovascular diseases. Abnormal HEY1 expression correlates with tumorigenesis in cancers such as osteosarcoma where it may interact with proteins like HES1 to influence tumor growth. Additionally HEY1's involvement in cardiovascular diseases links to its role in regulating vascular remodeling and heart development where an imbalance in HEY1 expression might contribute to pathological outcomes.