Abcam, ab317327, Anti-RIM1 antibody [EPR29131-34]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal RIMS1 antibody. Suitable for ICC/IF, Flow Cyt and reacts with Transfected cell line - Mouse, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR29131-34,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIM1 also known as Rab3-interacting molecule 1 is a protein with a mass of approximately 200 kDa. It serves as an important component in the exocytosis process by regulating synaptic vesicle release in the presynaptic terminal. RIM1 interacts with various proteins such as Munc13-1 and is integral to synaptic vesicle docking and priming. This protein predominantly expresses in the brain especially in areas with high synaptic transmission needs like the hippocampus and cortex.
Biological function summary
This protein acts as an organizer of active zones in the presynaptic neuron ensuring efficient neurotransmitter release. RIM1 is part of a larger complex known as the presynaptic active zone complex which includes other critical proteins like RIM-BP and ELKS. These interactions stabilize synaptic function and facilitate rapid neurotransmission. Additionally RIM1 has a role in modulating calcium channel activity which is essential for triggering synaptic vesicle fusion.
Pathways
Various neurological signaling processes rely on the function of RIM1. This protein plays important roles in the pathways of synaptic vesicle cycling and neurotransmitter release directly influencing synaptic strength and plasticity. RIM1 closely interacts with the Rab3 GDP-GTP cycle and Munc13 both of which participate in neurotransmitter release processes. Proper function of these pathways ensures precise neuronal communication and adaptation.
Any malfunction or mutation in RIM1 can significantly impact neurological health. The protein is linked to several neuropsychiatric disorders such as autism spectrum disorder and epilepsy. Researchers observed that disrupted RIM1 function correlates with aberrant synaptic transmission that can contribute to these conditions. In the context of epilepsy changes in RIM1 interaction with synaptic partners like RIM-BP and Munc13 can lead to irregular neuronal firing and seizures.