Abcam, ab317716, Alexa Fluor® 647 Anti-TCR delta antibody [EPR27043-16]

Size: 100µL
Rabbit Recombinant Monoclonal TRDC antibody - conjugated to Alexa Fluor® 647. Suitable for Flow Cyt (Intra), Flow Cyt and reacts with Transfected cell line - Human, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27043-16,
Isotype:IgG,
Conjugation:Alexa Fluor® 647,
Excitation/Emission:Ex: 650nm, Em: 665nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCR delta also known as T cell receptor delta chain is a component of the T-cell receptor complex found on gamma delta T cells. It has a molecular weight of approximately 60 kDa. TCR delta is expressed mainly in the thymus peripheral blood and epithelium. In the structure of TCR the delta chain pairs with the gamma chain to form a distinct type of TCR which differs from the more familiar alpha-beta TCR found on most T cells.
Biological function summary
TCR delta contributes to the immune response through recognition of antigens presented by non-classical MHC molecules such as those on stressed infected or transformed cells. It is an important player in the immune system with its expression often associated with mechanisms of immune surveillance and defense. TCR delta is part of a complex with CD3 proteins which are necessary for signal transduction leading to T cell activation. This chain together with the gamma chain enables recognition of a wide array of antigens contributing to immunity beyond typical peptide-dominated responses.
Pathways
Gamma delta T cells act in the immune response by recognizing stress-induced molecules and initiating protective reactions. TCR delta participates in signaling pathways that control T cell development and maturation including the MAPK and NF-κB pathways. These pathways involve interactions with proteins such as ERK JNK and IκB playing roles in the expansion and functional capabilities of T cells. The ability to recognize non-peptide antigens through TCR delta makes these pathways distinct in comparison to those mediated by alpha-beta TCR.
TCR delta has been associated with certain cancers and infectious diseases including tuberculosis. Gamma delta T cells with TCR delta exhibit cytotoxic activities against tumor cells and their infiltration can correlate with prognosis in cancer patients. Additionally the role of TCR delta in defense against infections involves interaction with other proteins such as heat shock proteins which are commonly expressed by infected cells. The activity of TCR delta in these contexts highlights its importance in immune regulation and potential as a target in therapeutic strategies.