Abcam, ab317816, Anti-FPRL1/RFP + FPR3 antibody [EPR28515-94] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FPRL1/RFP antibody. Carrier free. Suitable for IHC-P, ICC/IF and reacts with Transfected cell line, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28515-94,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for Mouse and Rat IHC

Product details:
ab317816 is the carrirer-free version of
ab317815
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FPRL1 also known as FPR2 or FPR3 is a G-protein coupled receptor (GPCR) with an approximate molecular mass of 38 kDa. It can interact with different ligands to regulate immune responses. You find this receptor expressed in various tissues particularly in leukocytes like neutrophils and monocytes as well as in the spleen and lung epithelial cells. This wide distribution points to a complex role in mediating immune cell signaling and responses to inflammation.
Biological function summary
FPRL1 engages in modulating inflammation and host defense against pathogens. It belongs to the GPCR family which plays a central role in cellular signaling networks. FPRL1 does not function alone but instead often associates with other proteins and receptors to navigate diverse immune responses. Its engagement with formyl peptides leads to activation of immune cells promoting chemotaxis degranulation and production of reactive oxygen species. This receptor is also involved in sensing danger signals participating in the clearance of apoptotic cells.
Pathways
FPRL1 influences the MAPK and NF-kB signaling pathways both important for immune response regulation and inflammation. The receptor's pathway interactions contribute to cellular responses like cytokine production and apoptosis regulation. FPRL1 interacts with related proteins such as FPR1 which share overlapping ligand specificity and functional roles. Through these pathways FPRL1 can modulate immune responses that protect the host from infection or contribute to inflammatory diseases.
FPRL1 has been linked to conditions like chronic inflammatory diseases and cancer. Its role in orchestrating inflammatory responses connects it to rheumatoid arthritis as its dysregulated signaling can exacerbate inflammation. FPRL1 is also associated with cancer progression by modulating the tumor microenvironment. In these contexts the receptor often interacts with proteins such as chemokine receptors which further highlights its multifaceted role in disease pathophysiology.