Abcam, ab317832, Anti-Ppp1r17 antibody [EPR29124-227] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PPR17 antibody. Carrier free. Suitable for IHC-P, WB, IP, IHC-Fr, mIHC and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR29124-227,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat,
Applications:IHC-Fr, mIHC, IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab317832 is the carrier-free version of
ab317831
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ppp1r17 also known as Protein Phosphatase 1 Regulatory Subunit 17 is a regulatory protein that modifies the activity of protein phosphatase 1 (PP1). It weighs approximately 10.5 kDa. Ppp1r17 acts by inhibiting PP1's ability to dephosphorylate its substrate proteins. It is expressed predominantly in the cerebellum and to some extent in other brain areas. The ability of Ppp1r17 to regulate PP1 suggests its importance in finely tuning brain functions and activities.
Biological function summary
Ppp1r17 serves a regulatory function in neuronal signaling and synaptic plasticity. It is not known to be part of a larger protein complex but rather it exists as a regulatory component modulating PP1 activity. Ppp1r17 plays a role in the regulation of signal transduction impacting processes such as synaptic strength and plasticity which are key for learning and memory in the brain. Its expression pattern reflects its potential involvement in modulating neuronal function and possibly other cell signaling processes.
Pathways
Ppp1r17 participates primarily in neuronal signaling cascades. It is involved in pathways linked to the modulation of synaptic plasticity and learning processes such as long-term potentiation and depression. Through these pathways Ppp1r17 is associated with proteins like PP1 itself and those involved in the regulation of synaptic strength such as NMDA receptors. This places Ppp1r17 within significant neuronal signaling frameworks that dictate responses to stimuli and environmental learning.
Ppp1r17's regulation of PP1 activity links it to neurological conditions like cerebellar ataxia and potentially schizophrenia. Misregulation of PP1 activity often affected by modifications in Ppp1r17 function can result in altered neuronal activity and contribute to these disorders. The interaction between Ppp1r17 and PP1 can be further connected to proteins like DARPP-32 which also influence dopaminergic neurotransmission and are implicated in neuropsychiatric conditions. By affecting these essential pathways and processes Ppp1r17's functional integrity is critical for maintaining healthy brain physiology.