Abcam, ab318206, Anti-TCR beta antibody [RM2056] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Multiclonal T Cell Receptor antibody. Carrier free. Suitable for WB, IHC-P, mIHC and reacts with Transfected cell lysate - Human, Transfected cell lysate - Mouse, Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RM2056,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:mIHC, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab318206 is the carrier-free version of
ab318205
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCR beta also known as T-cell receptor beta is an integral component of the T-cell receptor (TCR) complex. It weighs approximately 40-50 kDa and is expressed on the surface of T cells. TCR beta contributes to the recognition of antigens by interacting with peptide fragments presented by major histocompatibility complex (MHC) molecules. This interaction is essential for T-cell activation which plays a significant role in the adaptive immune response.
Biological function summary
TCR beta is part of the T-cell receptor complex. This complex is critical for antigen recognition and T-cell signaling. The complex comprises multiple subunits including CD3 chains that facilitate signal transduction upon antigen binding. This initiates a cascade of intracellular events leading to T-cell activation and proliferation. TCR beta's role in this complex makes it essential for recognizing pathogens and initiating immune responses.
Pathways
TCR beta is involved in T-cell receptor signaling and adaptive immune pathways. It is closely associated with the Zap70 protein which transmits activation signals from the TCR upon antigen recognition. This signaling cascade further activates the MAPK and NF-κB pathways influencing T-cell differentiation and cytokine production. The interaction between TCR beta and these pathways highlights its fundamental role in immune system regulation.
Dysregulation of TCR beta can contribute to autoimmune diseases and certain types of cancer. For instance aberrant TCR signaling can lead to autoimmunity where T cells attack the body's own tissues. Additionally in some leukemias mutations or rearrangements involving the TCR beta chain can promote uncontrolled cell proliferation. TCR beta's involvement with HLA proteins in autoimmune conditions showcases its significance in disease development and management.