Abcam, ab319992, Anti-EXOSC10/RRP6 antibody [EPR28902-62]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal EXOSC10/RRP6 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28902-62,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EXOSC10 also known as RRP6 is an important component of the RNA exosome complex which plays a role in RNA processing and degradation. This protein is approximately 97 kDa in mass. It is localized mainly in the nucleus with a high expression level in nucleoli. The EXOSC10 protein contributes to the catalytic core of the exosome allowing it to perform 3’ to 5’ exonuclease activity on a variety of RNA substrates.
Biological function summary
Beyond its activity as an exonuclease EXOSC10 participates in the degradation of aberrant RNA molecules and the maturation of stable RNA species like rRNA. As a member of the RNA exosome complex it functions alongside other core exosome components to maintain RNA homeostasis. This assembly is essential for the surveillance and decay of faulty RNA regulatory RNA and the normal turnover of cellular RNA. The process ensures fidelity in gene expression and the prevention of toxic RNA accumulation.
Pathways
EXOSC10 plays a significant role in RNA processing pathways that involve RNA surveillance and degradation mechanisms. It acts in coordination with other proteins such as DIS3 and EXOSC5 in these pathways to ensure the correct maturation and quality control of RNA. The RNA exosome including EXOSC10 intersects with the nonsense-mediated decay pathway a cellular mechanism that identifies and degrades mRNAs containing premature stop codons therefore preventing potential truncated protein production.
Defects in EXOSC10 have been linked to diseases such as various forms of cancer and autoimmunity. The malfunction of EXOSC10 can disrupt RNA processing and degradation leading to the accumulation of defective RNAs and misregulated gene expression contributing to oncogenesis. In autoimmune conditions abnormal RNA processing by EXOSC10 may lead to altered immune responses. Associations with RPL5 and other ribosomal proteins have also been noted in the context of these disorders highlighting the importance of EXOSC10 in maintaining cellular RNA balance and integrity.