Abcam, ab320638, Anti-CAMK2B/2D/2G (phospho T287) + CAMK2A (phospho T286) antibody [EPR28075-37]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal KCC2B phospho T287 antibody. Suitable for WB, Dot and reacts with Transfected cell lysate - Human, Human, Mouse, Rat, Synthetic peptide samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28075-37,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CaMKII (Ca2+/calmodulin-dependent protein kinase II) family consists of four isoforms: CaMKII alpha CaMKII beta CaMKII delta and CaMKII gamma also known respectively as CAMK2A CAMK2B CAMK2D and CAMK2G. These are serine/threonine-specific protein kinases with a molecular weight of around 50 to 60 kDa. They play a role in the phosphorylation of various downstream targets. These kinases are found in many tissues but CaMKII alpha is mostly found in brain tissue CaMKII beta in muscle tissue whereas CaMKII delta and gamma show more widespread expression across other tissues. The functional unit of CaMKII is a holoenzyme which forms a dodecamer consisting of 12 subunits.
Biological function summary
CaMKII isoforms participate in critical calcium signaling processes. They act to decode the frequency of calcium oscillations in cells and are involved in synaptic plasticity and memory formation. CaMKII alpha for example is highly active in the postsynaptic density where it can form complexes with both NMDA and AMPA receptors suggesting a role in the regulation of synaptic strength. While not part of a permanent complex CaMKII enzymes can transiently bind to other proteins during signaling events.
Pathways
CaMKII isoforms play significant roles in the calcium/calmodulin signal transduction pathway and the MAPK (mitogen-activated protein kinase) signaling cascade. In the calcium/calmodulin pathway CaMKII acts to mediate calcium-dependent phosphorylation events that affect neuronal and cardiac functions. It interacts with other pathway proteins such as calmodulin and CREB (cAMP response element-binding protein). In the MAPK pathway CaMKII modulates signals that control cell growth differentiation and response to cellular stress interacting with proteins like MEK and ERK.
CaMKII isoforms have connections to neurodegenerative diseases such as Alzheimer's disease and to cardiac conditions like heart failure. In Alzheimer's disease altered CaMKII activity can affect synaptic function linking to proteins like amyloid-beta peptides. In cardiac disorders abnormal CaMKII activation contributes to disrupted calcium homeostasis and arrhythmia where it interacts with proteins such as RyR2 (ryanodine receptor 2). Understanding these interactions highlights CaMKII's significance in both brain and heart health.