Abcam, ab320729, Anti-beta COP antibody [EPR28895-55]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal beta COP antibody. Suitable for ICC/IF, WB and reacts with Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28895-55,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta COP also known as coatomer subunit beta and sometimes referred to as beta COPI is an important component of the coatomer protein complex involved in vesicle formation and trafficking. This protein has a molecular mass of approximately 110 kDa. Beta COP is expressed widely across various tissues and is essential in maintaining cellular transport systems. It resides mainly within the cytosolic coat of COPI vesicles that originate from Golgi membranes helping in directing the flow of enzymes that are vital for cellular metabolism.
Biological function summary
Coatomer subunits like beta COP play an integral role in forming the COPI complex which functions as a coat on Golgi-derived transport vesicles. Beta COP acts to mediate retrograde transport from the Golgi apparatus back to the endoplasmic reticulum. By helping in vesicle budding and fusion processes it ensures correct protein sorting and localization. This mechanism is critical for cellular homeostasis and proper cellular functions.
Pathways
The COPI-mediated transport involving beta COP plays a significant role in the Golgi-to-ER retrograde transport pathway. This pathway is vital for maintaining the balance of lipids and proteins within cells. Key proteins interacting with this pathway include other coatomer subunits such as delta and gamma COP. Through these interactions beta COP is indispensable in regulating vesicle trafficking and membrane dynamics affecting overall cellular communication.
Beta COP's malfunction can lead to disruptions in vesicle transport potentially contributing to disorders like genetic syndromes or neurodegenerative diseases. Research suggests a connection between aberrant COPI transport and pathology such as Parkinson's disease where beta COP might interact with protein alpha-synuclein. Additionally alterations in beta COP's function link to Alzheimer’s disease where its dysfunction could impact amyloid precursor protein processing. Understanding these connections offers pathways to exploring therapeutic interventions.