Abcam, ab320819, Anti-UBR4/p600 antibody [EPR28593-48]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal UBR4/p600 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28593-48,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBR4 also known as p600 is a large protein with a molecular weight of approximately 600 kDa. It functions as an E3 ubiquitin ligase participating in the ubiquitin-proteasome system by tagging substrates for degradation. UBR4 is widely expressed in various tissues indicating its diverse functional impact throughout the body. It interacts with different proteins and contributes to many cellular processes influencing protein quality control and turnover.
Biological function summary
UBR4/p600 plays a role in cellular proliferation migration and adhesion. It is part of a complex involved in cytoskeleton organization and interacts with actin and microtubules. The protein supports cell shape and mechanical signaling especially during cellular differentiation and embryonic development. UBR4 also participates in autophagy contributing to cellular homeostasis and survival under stress conditions.
Pathways
UBR4/p600 is involved in the ubiquitin-mediated proteolysis pathway which regulates protein stability and activity. It is associated with the Wnt signaling pathway where it influences cell fate determination and tissue homeostasis. UBR4 interacts with other proteins like β-catenin and APC which are important in transmitting and modulating the Wnt signals affecting various developmental processes.
UBR4/p600 has been linked to neurodegenerative diseases like Alzheimer's disease and developmental disorders. Its aberrant regulation can impact protein degradation pathways contributing to protein aggregation and neuronal cell death. The protein is related to diseases through its interaction with tau a protein known to form pathological aggregates in Alzheimer’s. Additionally mutations in UBR4 have been associated with Joubert syndrome highlighting its role in cilia function and cerebellar development.