Abcam, ab322041, Anti-Orosomucoid 1 + Orosomucoid 2 antibody [EPR26603-6]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Orosomucoid 2 antibody. Suitable for Dot, WB and reacts with Recombinant full length protein - Human, Recombinant fragment - Human, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26603-6,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha 1 Acid Glycoprotein also known as AGP or Orosomucoid 2 is a plasma protein with a molecular mass of around 40-45 kDa. This glycoprotein is rich in carbohydrate content with about 45% of its mass made up of glycan chains. It is primarily synthesized in the liver and circulates in the bloodstream. AGP functions as a major acute-phase protein meaning its levels increase in response to inflammation or tissue injury.
Biological function summary
AGP has significant roles in modulating immune responses and transport functions. This molecule interacts with various drugs and hormones due to its binding capacity thereby influencing their bioavailability and distribution. It forms part of a complex dynamic system that helps modulate the body's response to acute inflammatory stimuli. As a glycoprotein AGP plays a role in processes such as cell-to-cell communication and cell signaling which are essential for maintaining homeostasis during stress responses.
Pathways
AGP is integrally involved in the acute-phase response pathway that gets activated during infection or injury. This pathway leads to the dramatic increase of AGP and other acute-phase proteins like C-reactive protein (CRP) in the blood. Furthermore AGP is related to the immune response pathways where it can modulate the activity of various immune cells. Its binding interactions with cytokines and other inflammatory modulators emphasize its role in regulating inflammation and immune responses.
AGP levels often correlate with conditions involving acute and chronic inflammation like rheumatoid arthritis and cancer. Elevated AGP levels are frequently observed in patients with these disorders and reflect the body's ongoing inflammatory response. The increase of AGP in these diseases often correlates with other proteins such as serum amyloid A (SAA) and CRP which serve similar functions in the acute-phase response. This correlation with other inflammatory markers highlights AGP's importance in understanding and potentially diagnosing inflammatory conditions.