Abcam, ab322800, Biotin Anti-proANP antibody [EPR22051-108] (Detector)

Size: 100µL
Rabbit Recombinant Monoclonal proANP antibody - conjugated to Biotin. Suitable for sELISA and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22051-108,
Isotype:IgG,
Conjugation:Biotin,
Carrier free:No,
Applications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The proANP also known as N-terminal pro-atrial natriuretic peptide (NT-proANP) is a biochemical precursor involved in the synthesis of atrial natriuretic peptide (ANP). This peptide is expressed mainly in the cardiac atrial myocytes. proANP has a molecular mass of approximately 28 kDa. The heart releases it in response to atrial stretch due to increased blood volume assisting the body in managing vascular homeostasis.
Biological function summary
NT-proANP participates in fluid balance and blood pressure regulation. It is part of a complex system involved in natriuresis which promotes sodium excretion via urine therefore reducing blood volume and pressure. ANP the active hormone plays a large role in vasodilation contributing to cardiovascular health by decreasing peripheral resistance and reducing cardiac workload.
Pathways
ProANP's role extends into the renin-angiotensin-aldosterone system (RAAS) and the natriuretic peptide system. Within these pathways NT-proANP acts to counterbalance the effects of angiotensin II and aldosterone which increase blood pressure and fluid retention. It has a significant relationship with protein NPPB also known as brain natriuretic peptide (BNP) both of which function to support cardiovascular stability and electrolyte balance.
NT-proANP has connections to conditions like heart failure and hypertension. Elevated levels of NT-proANP may indicate heart failure as the heart releases more peptides in response to increased atrial pressure. NT-proANP's relationship with NPPB is clinically useful as both markers are used to diagnose and monitor heart failure. Their combined expression offers insights into cardiac function and the efficacy of therapeutic interventions.