Abcam, ab32914, FITC Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) antibody

Size: 500µL
Rabbit Polyclonal HBSAG antibody - conjugated to FITC. Suitable for ICC and reacts with Hepatitis B virus samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Conjugation:FITC,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Hepatitis B virus,
Applications:ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody recognizes Hepatitis B Surface Antigen, subtypes ad and ay.

Properties and Storage Information:
Form-Liquid, Purification notes-This antibody was purified to monospecific FITC., Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Hepatitis B Virus Surface Antigen (HBsAg) also known as Hepatitis B surface antigen AD/AY serves as a significant marker for the Hepatitis B virus (HBV). This glycoprotein displays a molecular mass of approximately 24 kDa and consists of small medium and large protein forms. HBsAg is typically expressed in the infected liver cells and secreted into the bloodstream. This expression allows its use as a diagnostic marker for HBV infection through assays like HBsAg ELISA which detects the presence of the virus.
Biological function summary
The surface antigen plays an important role in the virus's attachment and entry into hepatocytes. HBsAg forms part of the viral envelope structure which facilitates the virus's ability to infect host cells. The presence of HBsAg is linked to an individual’s immune response specifically the production of hepatitis antibodies. Its interaction with the host’s immune system and antibodies like hep B antibodies are essential for understanding both viral pathogenesis and immunity to HBV infections.
Pathways
The Hepatitis B virus surface antigen plays critical parts in the infectious cycle and immune response pathways. One important pathway includes the endocytosis pathway where HBsAg is involved in the virus's entry into liver cells. The surface antigen also interacts with the human immune system influencing the expression of Hepatitis B antibodies. Connected proteins include those involved in the immune signaling where alterations affect the body's ability to mount an effective response against HBV.
The Hepatitis B Virus Surface Antigen is directly associated with Hepatitis B infection and its progression. Chronic HBV infection may lead to liver-related diseases such as cirrhosis and hepatocellular carcinoma. HBsAg presence serves as an indicator for diagnosing these liver diseases. The antigen's interaction with other viral proteins such as the core antigen and E antigen are important in the disease's progression and overall clinical outcomes.