Abcam, ab33168, Anti-VE Cadherin antibody - Intercellular Junction Marker

Size: 100µg
Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168) is a rabbit polyclonal antibody detecting VE Cadherin in Western Blot, ICC/IF . Suitable for Human, Mouse . - Over 360 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From May 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Product details:
Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168) is a rabbit polyclonal antibody and is validated for use in ICC/IF, WB in mouse, rat samples.
Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168) has been cited over 361 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168) has high sensitivity and specificity.
Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168) has 39 independent reviews from customers.
Anti-VE Cadherin antibody - Intercellular Junction Marker (ab33168) specifically detects VE Cadherin (UniProt ID: P33151; Molecular weight: 83kDa) and is sold in 100 µg selling sizes.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
VE Cadherin also known as Cadherin-5 or CD144 is a type of protein with a mass of approximately 120 kDa. It is mainly found in endothelial cells where it plays an important role in maintaining endothelial integrity and stability. As a member of the cadherin family VE Cadherin facilitates cell-cell adhesion by interacting with other cadherins on adjacent cells through its extracellular domain. This protein helps form adherens junctions important structures that stabilize cell layers and maintain tissue architecture.
Biological function summary
VE Cadherin functions as an important component in maintaining vascular integrity. It connects to cytoskeletal elements through catenins forming a complex that transmits mechanical signals to maintain junctional stability. This ability is integral to the control of vascular permeability and the regulation of endothelial cell movement and growth. The anchoring of VE Cadherin to the actin cytoskeleton ensures that endothelial cells remain tightly bound limiting permeability and preventing unwarranted fluid leakage.
Pathways
VE Cadherin participates in the Wnt/β-catenin pathway and the Rho GTPase signal transduction. In the Wnt/β-catenin pathway VE Cadherin interacts with β-catenin playing a pivotal role in mediating cell signaling that governs cell proliferation and differentiation. In the Rho GTPase pathway VE Cadherin influences cytoskeletal dynamics and cell morphology through interactions with small GTPases such as RhoA. These pathways highlight VE Cadherin's involvement in cellular processes including cell movement and stability.
VE Cadherin has associations with cancer progression and cardiovascular diseases. In cancer alterations in VE Cadherin expression can lead to increased tumor angiogenesis and metastasis due to disrupted cell adhesion. In cardiovascular contexts abnormalities in VE Cadherin contribute to vascular permeability changes seen in conditions like atherosclerosis. Proteins such as β-catenin and p120-catenin which partner with VE Cadherin also play roles in these pathological processes further emphasizing its importance in disease mechanisms.