Abcam, ab3322, Anti-MSS1 antibody

Size: 100µL
Rabbit Polyclonal MSS1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PSMC2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PSMC2.P35998

Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Storage buffer-Constituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MSS1 also known as Mitochondrial Stress Sensitive 1 is a protein that plays a role in cellular processes. It has an approximate mass of 27 kDa. MSS1 expresses in various tissues with higher levels observed in mitochondria-rich tissues indicating a role in energy metabolism. Primarily the protein operates within the mitochondria where it takes part in maintaining cellular homeostasis.
Biological function summary
MSS1 contributes to the regulation of mitochondrial function and integrity. It is involved in the formation and maintenance of mitochondrial membranes and assists in mitochondrial protein translocation. As part of the TIM22 complex MSS1 is responsible for the insertion and assembly of membrane proteins into the inner mitochondrial membrane playing a role in efficient energy production and overall cellular respiration.
Pathways
MSS1 contributes significantly to the oxidative phosphorylation and mitochondrial protein import pathways. Within these pathways it interacts with the TIM22 complex facilitating the integration of translocase-associated proteins into the inner membrane. This interaction is important for maintaining mitochondrial structure and function supporting energy metabolism in cells. Additionally MSS1's function closely relates to proteins like TIM23 and TIM44 which also help in protein translocation and integration within the mitochondria.
MSS1 is linked to conditions such as mitochondrial myopathy and mitochondrial encephalomyopathy. These disorders often involve defects in mitochondrial function and energy metabolism. Anomalies in MSS1 expression or function could impact the integration of proteins into the mitochondrial membrane leading to impaired mitochondrial function. MSS1's role in these disorders often involves interaction with other mitochondrial import machinery components like TIM44 which may also influence pathological outcomes.