Abcam, ab3331, Anti-Proteasome 20S beta 6 antibody

Size: 100µg
Rabbit Polyclonal PSB6 antibody. Suitable for WB, ICC/IF and reacts with Rat, Human, Mouse, Cow samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PSMB6 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Cow, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PSMB6 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P28072,
Specificity:Detects proteasome 20S beta 6 from purified bovine and human 26S proteasome samples.

Product details:
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Constituents: 15% Sodium chloride, 3% Triton X-100, 3% Sodium deoxycholate, 0.3% Tris HCl, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Proteasome 20S beta 6 also known as PSMB6 is a subunit of the proteasome complex. It plays a significant role in the protein degradation process. Its molecular weight is around 25 kDa. The subunit gets expressed in various cell types throughout the body ensuring that proteins are effectively broken down into peptides. This is essential for maintaining protein homeostasis and recycling faulty proteins.
Biological function summary
The proteasome 20S beta 6 subunit forms part of the 20S core complex an important component of the proteasome. The proteasome operates as the main proteolytic machinery in both nucleus and cytoplasm. The 20S core complex pairs with the regulatory 19S cap to form the 26S proteasome. This assembly degrades ubiquitin-tagged proteins which regulates cell cycle progression apoptosis and DNA repair contributing to cellular function and health.
Pathways
Proteasome 20S beta 6 acts within the ubiquitin-proteasome pathway. This pathway regulates protein turnover affecting critical cellular processes such as cell cycle apoptosis and the immune response. The pathway also links with other proteins such as ubiquitin and E1 E2 and E3 ligases which modify proteins with ubiquitin chains to signal for their degradation.
Proteasome 20S beta 6 may relate to cancer and neurodegenerative diseases like Alzheimer's. The abnormal regulation of the proteasome pathway can lead to the accumulation of undegraded proteins contributing to these diseases. PSMB6 interacts with proteins such as p53 a tumor suppressor protein highlighting its relevance to cell cycle control and cancer progression.