Abcam, ab3344, Anti-SynGAP antibody

Size: 100µg
Rabbit Polyclonal SynGAP antibody. Suitable for IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat Syngap1 aa 900-1200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat Syngap1 aa 900-1200. The exact immunogen used to generate this antibody is proprietary information.Q9QUH6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Constituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SynGAP also known as Synaptic Ras GTPase-activating protein 1 has a molecular weight of about 138 kDa. It predominantly expresses in the brain especially in the post-synaptic density of neurons. SynGAP acts mechanically by regulating Ras and Rap GTPase signaling through its GTPase-activating protein (GAP) domain. This protein modulates synaptic strength and plasticity by influencing the activity of these GTPases which are pivotal for intracellular signaling.
Biological function summary
SynGAP influences synaptic function and plasticity. It forms part of the NMDA receptor complex linking it to various synaptic signaling pathways. SynGAP modulates excitatory synaptic transmission by controlling the levels of Ras and Rap GTPases which impact the phosphorylation of AMPA receptors. Through these activities it maintains proper synaptic strength and structural integrity essential for learning and memory processes.
Pathways
SynGAP interfaces with signaling networks critical for neuronal function such as the MAPK/ERK and PI3K/Akt pathways. In these pathways SynGAP regulates Ras-related protein kinase activity influencing downstream effects on gene expression and cellular survival. The protein's interaction with other partners like the PSD-95 and other MAGUK family proteins highlights its central role in controlling synaptic signaling cascades.
Researchers link SynGAP to neurodevelopmental disorders like intellectual disability and autism spectrum disorders. Mutations or disruptions in SynGAP levels correlate with altered synaptic function and contribute to these conditions. SynGAP also interacts with proteins such as SHANK3 which connects to synaptic abnormalities observed in these disorders. Understanding its role in such conditions can provide insights into potential therapeutic targets.