Abcam, ab33682, Anti-LYVE1 antibody

Size: 100µg
Anti-LYVE1 antibody (ab33682) is a rabbit polyclonal antibody detecting LYVE1 in IHC-P, ICC/IF . Suitable for Mouse . - Over 40 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From July 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Product details:
Anti-LYVE1 antibody (ab33682) is a rabbit polyclonal antibody and is validated for use in ICC, IHC-P in mouse samples.
Anti-LYVE1 antibody (ab33682) has been cited over 47 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-LYVE1 antibody (ab33682) has high sensitivity and specificity.
Anti-LYVE1 antibody (ab33682) has 12 independent reviews from customers.
Anti-LYVE1 antibody (ab33682) specifically detects LYVE1 (UniProt ID: Q9Y5Y7; Molecular weight: 33kDa) and is sold in 100 µg selling sizes.
LYVE-1 (Lymphatic Vessel Endothelial Receptor 1) is primarily expressed on lymphatic endothelial cells and plays a crucial role in hyaluronan (HA) transport and turnover. It is also involved in lymphangiogenesis and immune responses, with altered LYVE-1 expression linked to various diseases, including cancer and inflammatory conditions. For instance, LYVE-1 expression is downregulated in human liver cancer and cirrhosis. Additionally, it is linked to intramuscular hemangioma and complete androgen insensitivity syndrome. Changes in LYVE-1 expression can impact lymphangiogenesis and immune responses, contributing to disease progression.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein "LYVE1" also known as Lymphatic Vessel Endothelial Hyaluronan Receptor 1 has a molecular mass of about 60 kDa. This protein is located on the surface of lymphatic endothelial cells. Its expression occurs mainly within the lymphatic vessels serving as an important marker for identifying lymphatic endothelium. LYVE1 facilitates the transportation of hyaluronan an important glycosaminoglycan through lymphatic vessels playing a critical role in the maintenance of extracellular matrix and tissue fluid homeostasis.
Biological function summary
LYVE1 plays a role in lymphatic system regulation and immune cell trafficking. It forms part of a network that binds hyaluronan contributing to the regulation of cell migration and adhesion. This protein interacts with molecules like CD44 and other receptors which also participate in hyaluronan binding. LYVE1's function in maintaining the balance of hyaluronan within tissues is central affecting not only the lymphatic system but also immune responses.
Pathways
LYVE1 engages in both the hyaluronan metabolism and lymphangiogenesis pathways. Its interaction with CD44 plays a significant role in the transport and uptake of hyaluronan influencing cellular processes such as proliferation and motility. These interactions link LYVE1 to pathways controlling fluid balance and immune surveillance marking it as essential for maintaining healthy lymphatic and immune function.
LYVE1 shows a connection to lymphatic-related conditions such as lymphedema and cancer metastasis. Alterations or dysregulation of LYVE1 expression can affect lymphatic function potentially leading to the accumulation of interstitial fluid as seen in lymphedema. In cancer increased LYVE1 expression can relate to tumor metastasis where it functions alongside proteins like VEGFR-3 in promoting lymphatic vessel growth and facilitating cancer cell spread.