Abcam, ab3475, Anti-Kif2a antibody

Size: 200µL
Rabbit Polyclonal KIF2A antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Detects Kinesin 2 (Kif2a) from mouse tissues.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kif2a known as Kinesin family member 2A is a motor protein involved in microtubule dynamics. It has a mass around 93 kDa and provides mechanical force by depolymerizing microtubules. Kif2a expresses mainly in the brain but shows presence in other tissues as well. By regulating microtubule dynamics Kif2a plays a role in cellular assembly processes including mitotic spindle formation and chromosome segregation during cell division.
Biological function summary
Kif2a assists in microtubule destabilization and plays a critical role in ensuring proper mitotic spindle assembly. It doesn't function alone but interacts with other proteins to exert its function. Kif2a forms part of a machinery complex responsible for chromosome alignment and segregation. This complex action contributes significantly to the accuracy of cell division ensuring cell viability.
Pathways
The Kif2a protein engages in critical cellular pathways like the spindle assembly checkpoint and chromosomal passenger complex pathway. Kif2a's activity influences the Aurora B kinase a major regulator in the chromosome segregation process. Through these interactions it secures the maintenance of genomic stability by preventing improper chromosome segregation and aneuploidy.
Kif2a's dysfunction links to neurodevelopmental disorders and various cancers. Impaired function in neural development can relate to altered Kif2a activity affecting brain development processes. Furthermore abnormal Kif2a expression found in cancer cells shows its involvement in oncogenesis. In neurodevelopmental disorders its interaction with proteins like Lis1 connects it to abnormalities in neuronal migration highlighting its critical impact on neural health.