Abcam, ab34750, Anti-Cbl-c antibody

Size: 100µg
Rabbit Polyclonal Cbl-c antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CBLC aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CBLC aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9ULV8,
Specificity:This affinity purified antibody is directed against human Cbl-c protein. A BLAST analysis was used to suggest that this antibody would react with Cbl-c from human and chimpanzee sources. Expect partial reactivity against mouse and rat sources of Cbl-c as ~83% sequence homology is on record for the immunogen sequence. Reactivity with Cbl-c from other sources has not been determined. No reactivity is expected with Cbl-a or Cbl-b.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The product was affinity purified from monospecific antiserum by immunoaffinity purification., Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cbl-c also known as Casitas B-lineage lymphoma protein C is a member of the Cbl family of ubiquitin ligases. This protein has an approximate mass of 56 kDa and is expressed in various tissues including skeletal muscle and the uterus. Cbl-c functions as an E3 ubiquitin-protein ligase which means it tags target proteins for degradation by the proteasome. By doing so it regulates protein turnover and maintains cellular protein balance.
Biological function summary
Cbl-c interacts with signaling complexes and modulates signal transduction pathways. It participates in processes such as negative regulation of tyrosine kinase signaling. Cbl-c operates alongside other proteins in the Cbl family including Cbl and Cbl-b to downregulate signaling through ubiquitination. It plays a significant role in the regulation of cellular growth and differentiation by targeting specific proteins for degradation.
Pathways
Cbl-c interacts with cellular signaling mechanisms involved in the regulation of growth and cellular response. Cbl-c is an important component of pathways like the Epidermal Growth Factor Receptor (EGFR) signaling pathway and the Insulin signaling pathway. Through these pathways Cbl-c also interacts with receptor tyrosine kinases such as EGFR and insulin receptors impacting cellular processes like proliferation migration and apoptosis.
Mutations or dysregulation of Cbl-c have associations with tumor progression and metabolic disorders. Cancer and insulin resistance are two conditions in which alterations in Cbl-c function contribute to disease pathology. Interactions with proteins such as EGFR and insulin receptor through these disorders highlight Cbl-c’s involvement in critical regulatory networks impacting human health.