Abcam, ab3522, Anti-GNAI1 + GNAI2 antibody

Size: 100µg
Rabbit Polyclonal GNAI1 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human GNAI1 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GNAI1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P63096,
Specificity:Similarity with other sequences from the G protein family is predicted but has not being tested empirically.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNAI1 and GNAI2 also known as Gαi1 and Gαi2 are G protein subunits that belong to the Gi/Go family of proteins. These proteins have a molecular mass of approximately 40 kDa each. Mechanically they inhibit the production of cyclic AMP (cAMP) by binding to adenylate cyclase. GNAI1 and GNAI2 are expressed throughout various tissues including the brain heart and immune cells where they play a role in signal transduction processes.
Biological function summary
These proteins modulate intracellular signaling by interacting with seven-transmembrane domain receptors. GNAI1 and GNAI2 participate in heterotrimeric G protein complexes acting as transducers in signal transduction pathways. They are key players in mediating receptor responses to hormones and neurotransmitters influencing cellular responses such as growth migration and secretion.
Pathways
GNAI1 and GNAI2 significantly influence the cAMP-dependent signaling pathway and the PI3K-Akt signaling pathway. These pathways are critical for cellular functions like cell proliferation and survival. GNAI proteins including GNAI1 and GNAI2 often interact with other proteins like adenylate cyclase and phosphoinositide 3-kinases (PI3Ks) to modulate these pathways and ensure proper cellular responses.
GNAI1 and GNAI2 have been linked to specific conditions such as hypertension and some immune disorders. Hypertension involves complex interactions where GNAI1 and GNAI2 modulate vascular tone through cAMP signaling. Furthermore these proteins connect to signaling components like adrenergic receptors and other G proteins in disease contexts impacting disease pathogenesis and progression.