Abcam, ab3533, Anti-PCSK2 antibody

Size: 100µg
Rabbit Polyclonal PCSK2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Mouse Pcsk2 aa 600 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Pcsk2 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P21661

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PCSK2 also known as proprotein convertase 2 is an enzyme with a molecular mass of approximately 75 kDa. It functions by processing various precursor proteins into their active forms. PCSK2 belongs to the family of serine proteases and is mainly expressed in endocrine and neuroendocrine tissues including the pituitary gland kidneys and pancreas. This protein is important in the maturation of peptide hormones and neuropeptides impacting physiological functions.
Biological function summary
PCSK2 is responsible for activating various prohormones into their active hormone counterparts. It accomplishes this by cleaving specific sites on precursor proteins. PCSK2 does not operate as part of a complex but independently participates in proteolytic processing essential for proper hormone functioning. This enzyme's activity is critical for the synthesis of key hormones like insulin and glucagon which regulate glucose metabolism.
Pathways
PCSK2 is a significant part of hormone processing pathways. Specifically it contributes to the insulin-processing pathway which is important for energy regulation and homeostasis. PCSK2 works closely with related proteins such as PCSK1 (proprotein convertase 1) in the cleavage of precursor forms of various hormones. The coordinated action of these enzymes ensures the production of bioactive hormones required for normal metabolic functions.
PCSK2 is associated with conditions like diabetes and obesity due to its role in processing hormones that regulate metabolism. Dysregulation or mutations in the PCSK2 gene can disrupt insulin and glucagon maturation leading to imbalances in blood sugar levels. Additionally variations in PCSK2 may influence fat storage and energy expenditure contributing to obesity. The interaction between PCSK2 and insulin-related pathways highlights its importance in maintaining metabolic health.