Abcam, ab35336, Anti-NPY1R antibody

Size: 500µL
Sheep Polyclonal NPY1R antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human NPY1R aa 350 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Sheep,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NPY1R aa 350 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P25929

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Ammonium Sulphate fractionation., Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuropeptide Y receptor Y1 (NPY1R) also known simply as NPY1R is a G protein-coupled receptor involved in the mechanical action of neuropeptide Y peptide YY and pancreatic polypeptide. It weighs approximately 48 kDa. This receptor is mostly expressed in the central nervous system including the hypothalamus as well as regions like the amygdala. It also appears in peripheral tissues such as the heart blood vessels and kidneys.
Biological function summary
NPY1R plays a role in regulating various physiological processes. As a part of the neuropeptide Y receptor family it helps control food intake anxiety and circadian rhythms. NPY1R influences energy homeostasis and mediates vasoconstriction. This receptor plays an essential role in stress responses where its activation can help modulate the body’s response to stressful stimuli.
Pathways
NPY1R functions in pathways like the neuropeptide Y pathway and the hypothalamic-pituitary-adrenal (HPA) axis. In the neuropeptide Y pathway NPY1R interacts with other receptors such as NPY2R and NPY5R facilitating the signaling cascades that influence appetite and energy balance. NPY1R impacts the HPA axis by affecting cortisol release integrating signals that control stress responses.
NPY1R has been implicated in conditions such as obesity and anxiety disorders. The receptor's role in regulating food intake and energy homeostasis links it to the development of obesity. Anxiety disorders connect to NPY1R through its modulation of stress responses where its interaction with proteins such as corticotropin-releasing hormone (CRH) receptors can further influence anxiety symptoms and stress management.