Abcam, ab3571, Anti-CYP2C11 antibody

Size: 100µL
Rabbit Polyclonal CYP2C11 antibody. Suitable for IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Rat Cyp2c11 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.Synthetic Peptide within Rat Cyp2c11 aa 450 to C-terminus. Database linkP08683

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2C11 also known as Cytochrome P450 2C11 is an enzyme that plays an important role in the metabolism of drugs and steroids in rats. This enzyme belongs to the Cytochrome P450 superfamily and weighs approximately 55 kDa. It is expressed in the liver and its presence is linked to the metabolism of various endogenous and exogenous compounds. CYP2C11 has a specific role in the hydroxylation reactions that are part of these metabolic processes.
Biological function summary
Cytochrome P450 2C11 participates in the metabolism of steroids through oxidative reactions. It plays a role in converting testosterone into its hydroxylated metabolites which are important for maintaining homeostasis. CYP2C11 often acts independently but can also be associated with other proteins that facilitate the electron transfer needed for oxygenation reactions. Its activity can be influenced by factors like hormonal changes and stress.
Pathways
CYP2C11 contributes significantly to the lipid metabolism pathway and drug metabolism pathway. It has functional relevance in transforming chemicals that are either taken up by the body or produced within it. The enzyme CYP3A1 shares a functional relationship with CYP2C11 in these pathways broadening the spectrum of compounds processed. The modulation of CYP2C11 affects the concentrations of various metabolites impacting systemic homeostasis.
CYP2C11 relates to hepatic diseases and hormone imbalance disorders. Changes in the activity of this enzyme are observed in liver dysfunction which affects the body's ability to process drugs and hormones effectively. The enzyme also connects to proteins such as CYP2C6 which can be altered in similar disorders further affecting metabolic homeostasis. Accurate and reliable study of CYP2C11 may help in understanding the biochemical underpinnings of these conditions better and developing targeted treatments.