Abcam, ab36057, Anti-GLUT5 antibody

Size: 50µL
Rabbit Polyclonal GLUT5 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human SLC2A5 aa 450-500 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC2A5 aa 450-500 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P22732,
Specificity:Does not react with GLUT1, 2, 3 or 4 from human, mouse or rat.

Product details:
Concentration is approximately 5 mg/ml.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLUT5 also known as SLC2A5 is a fructose transporter protein that is part of the class II facilitative glucose transporter family. This protein has a molecular mass of approximately 58 kDa. It is highly expressed in the small intestine where it facilitates the uptake of dietary fructose into enterocytes. GLUT5 is also found in other tissues including the kidney testis skeletal muscle and fat tissue but at lower levels.
Biological function summary
GLUT5 plays a vital role in fructose metabolism and energy homeostasis. It functions as a carrier protein mediating the passive transport of fructose along its concentration gradient. GLUT5 does not form a complex with other transporters but works alongside them like GLUT2 which is responsible for fructose export from enterocytes into the bloodstream.
Pathways
GLUT5 is significantly involved in carbohydrate digestion and absorption pathways. It interacts with proteins like GLUT2 during the process of fructose transport across the intestinal epithelium. This functional interaction is key in maintaining normal blood sugar levels and ensuring efficient nutrient absorption post-digestion.
Improper function of GLUT5 relates to fructose malabsorption and metabolic conditions such as obesity. Fructose malabsorption can cause gastrointestinal distress and contribute to irritable bowel syndrome. Furthermore GLUT5 expression studies in obesity link it to other proteins like leptin which influences appetite and energy balance.