Abcam, ab36852, Anti-NLRP1 antibody

Size: 100µg
Rabbit Polyclonal NLRP1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human NLRP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NLRP1. The exact immunogen used to generate this antibody is proprietary information.Q9C000

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NLRP1 also known as NACHT LRR and PYD domains-containing protein 1 plays an important role in inflammasome formation as a sensor of cellular stress. It has a molecular mass of approximately 164 kDa. You can find its expression primarily in human immune cells like macrophages and dendritic cells. NLRP1 contains an N-terminal pyrin domain a central nucleotide-binding domain and leucine-rich repeats which contribute to its function in detecting danger signals.
Biological function summary
NLRP1 acts as an activator of the inflammasome a multiprotein complex essential for inflammation and host defense mechanisms. Upon activation NLRP1 recruits and promotes Caspase-1 activation leading to the processing and secretion of pro-inflammatory cytokines such as IL-1β and IL-18. This process takes place within the innate immune response facilitating the body's reaction to infection and cellular damage.
Pathways
NLRP1 plays significant roles in both the innate immune signaling pathway and the broader inflammatory response pathway. Within these pathways NLRP1 interacts with proteins such as ASC (apoptosis-associated speck-like protein containing a CARD) enhancing the rapid assembly of the inflammasome complex and subsequent cytokine production. Its function intertwines closely with other NOD-like receptors and signaling proteins intersecting various immune-regulatory processes.
NLRP1 links to autoimmune conditions and hereditary diseases such as autoimmune diseases and vitiligo. Mutations or dysregulation of NLRP1 result in uncontrolled inflammasome activation contributing to the pathogenesis of these diseases. The interplay between NLRP1 and protein partners like IL-1β a downstream product underlies their involvement in disease processes and informs potential therapeutic targets.