Abcam, ab37072, Anti-TLR6 antibody

Size: 100µg
Rabbit Polyclonal TLR6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human TLR6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TLR6. The exact immunogen used to generate this antibody is proprietary information.Q9Y2C9,
Specificity:TLR6 antibody is specific to TLR6. It does not recognize TLR1.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody was purified by affinity chromatography., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Toll-like receptor 6 (TLR6) acts as an important component of the innate immune system. TLR6 is alternatively known as CD286 and has an approximate molecular mass of 91 kDa. This protein is predominantly expressed in immune cells such as monocytes dendritic cells and macrophages. It localizes mainly on the cell surface and is involved in recognizing pathogen-associated molecular patterns specifically diacyl lipopeptides and peptidoglycans.
Biological function summary
TLR6 plays a role in pathogen recognition and activation of inflammatory responses. It often forms a functional heterodimer with TLR2 a necessity for its function. Through this complex TLR6 mediates the recognition of bacterial lipoproteins and triggers downstream signaling involved in immune cell activation and cytokine production. This signaling increases the host's immune response to bacterial infections by promoting the release of pro-inflammatory cytokines.
Pathways
TLR6 initiates signaling cascades that are significant in the immune system such as the NF-kB and MAPK pathways. TLR6 partners with TLR2 to activate the MyD88-dependent signaling pathway an important pathway in innate immunity that affects transcription of pro-inflammatory genes. Interaction with these pathways involves proteins like MyD88 and TRAF6 which are central components in signal transduction leading to inflammation and antimicrobial responses.
TLR6 contributes to the pathogenesis of inflammatory and autoimmune diseases. Research indicates its association with conditions like rheumatoid arthritis and asthma where it influences inflammation levels and immune system dysregulation. TLR6 through its interaction with TLR2 affects the differentiation and activation of immune cells leading to overactive immune responses observed in these disorders. Its role in inflammation makes it a potential target for therapeutic intervention in diseases related to immune system dysfunction.