Abcam, ab37113, Anti-CoREST2 / RCOR2 antibody

Size: 100µg
Rabbit Polyclonal CoREST2 / RCOR2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CoREST2 also known as RCOR2 is a corepressor protein weighing approximately 58 kDa. Mechanically CoREST2 functions by interacting with transcription factors and chromatin. It participates in remodeling chromatin structure which affects gene expression regulation. CoREST2 is primarily expressed in the brain but can be found in other tissues. Its interactions occur through its domains allowing it to bind with other proteins and DNA.
Biological function summary
CoREST2 contributes to transcriptional repression and gene silencing. CoREST2 frequently forms part of larger protein complexes including the CoREST complex involving LSD1 and HDACs. This complex modulates chromatin to suppress specific genes particularly those associated with neuron differentiation and development. CoREST2 supports maintaining the silenced state of various genes participating in controlling cellular functions and fate.
Pathways
Multiple processes rely on CoREST2 for maintaining gene expression regulation especially in neural pathways. It participates in pathways associated with neural differentiation and development. Through its association with the REST complex CoREST2 modulates neuronal genes alongside proteins like REST and LSD1. These pathways control how stem cells develop into neurons and maintain neural populations important for brain function.
CoREST2 has links to neurological conditions such as neurodevelopmental disorders and epilepsy. Its role in gene silencing connects CoREST2 to disorders resulting from disrupted gene regulation. In these contexts CoREST2 dysregulation might affect the balance of genes associated with developmental processes alongside proteins like HDAC2 contributing to disease development. Understanding CoREST2's functions could offer insights into therapeutic approaches for these conditions.