Abcam, ab40798, Anti-b-Myc antibody [EP643Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal b-Myc antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP643Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
B-Myc also known as B-Myc or MYCL is a member of the Myc family of transcription factors. It is an essential regulator in cellular processes like growth and differentiation. The molecular weight of b-Myc is approximately 24 kDa. This protein acts as a transcriptional repressor and is mainly expressed in tissues such as the mammary gland lung and prostate. It plays a part in suppressing the Myc-mediated gene expression by competing for the same DNA binding sites thereby offering a balance to the functions of other Myc proteins.
Biological function summary
B-Myc functions to modulate transcriptional activities that are necessary for cellular homeostasis. It can associate with other proteins and is often considered part of transcriptional repression complexes. These complexes contribute to regulating gene expression achieving this by directly binding to target DNA sequences or interacting with other transcription factors and co-repressors. Its activities significantly impact cellular differentiation and proliferation providing checks and balances against other members of the Myc family that promote cellular growth.
Pathways
B-Myc is involved in pathways that play a critical role in cell cycle regulation and apoptosis. It actively participates in the Myc signaling pathway where its presence helps counterbalance the more proliferative effects of c-Myc and N-Myc. By doing so it interacts with proteins like Max enabling the formation of different dimers with varying transcriptional roles. Additionally b-Myc's activity within these pathways suggests an intriguing role in modulating cellular responses to growth signals and stressors.
B-Myc's expression and functioning relate to cancer development particularly in breast and prostate cancers. Its capacity to restrain Myc-driven transcriptional programs implies that deviations in b-Myc expression can lead to unregulated cell proliferation and tumorigenesis. In cancerous contexts alterations in b-Myc's interactions with proteins such as EZH2 a component of the PRC2 complex highlight its potential implication in the disruption of normal cellular stability. Understanding b-Myc's role in these diseases offers insights into targeted therapeutic strategies where inhibiting or modulating its function could yield beneficial outcomes.