Abcam, ab40916, Anti-JDP2 antibody

Size: 100µg
Rabbit Polyclonal JDP2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JDP2 also known as Jun dimerization protein 2 is a small protein with a mass of approximately 19 kDa. It functions mechanically as a transcription factor and modulates the activity of gene expression by interacting with other proteins. JDP2 expresses in various tissues including the brain and liver. It forms dimers with components of the AP-1 transcription factor family allowing it to regulate different gene expression profiles.
Biological function summary
JDP2 influences cellular functions such as proliferation and differentiation. It acts as a repressor of AP-1 activity playing an essential role in controlling gene expression in response to extracellular signals. JDP2 participates in transcriptional complexes interacting with histone deacetylases and other proteins to modulate chromatin structure and consequently transcriptional activity.
Pathways
The regulation of immune response and cell cycle processes involve JDP2. It interacts in the MAPK signaling pathway influencing genes that govern cell proliferation and survival. Additionally JDP2 relates to proteins like c-Jun and ATF3 in these pathways contributing to the fine-tuning of transcriptional outcomes following various stimuli.
JDP2 plays roles in cancer and neurodegenerative diseases. Altered JDP2 expression occurs in certain cancers affecting cell proliferation and survival pathways. In the context of neurodegenerative diseases JDP2 might influence apoptotic pathways related to proteins like Bcl-2 contributing to neuronal survival. Understanding JDP2's role in these diseases could provide insights into potential therapeutic targets.