Abcam, ab41671, Anti-Japanese encephalitis virus E glycoprotein antibody [JE1]

Size: 1mL
Anti-Japanese encephalitis virus E glycoprotein antibody [JE1] (ab41671) is a mouse monoclonal antibody detecting Japanese encephalitis virus E glycoprotein in Western Blot, ICC/IF, ELISA, Dot Blot . Suitable for Japanese encephalitis virus . - Trusted since 2006
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:JE1,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Japanese encephalitis virus,
Applications:ICC/IF, Dot, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Japanese encephalitis virus E glycoprotein antibody [JE1] (ab41671) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA, Dot Blot in Japanese encephalitis virus samples.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.1% Proclin 150Constituents: 89.9% RPMI 1640, 10% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Japanese encephalitis virus E glycoprotein also known as JEV E is a structural protein playing an important role in viral entry into host cells. It is expressed on the surface of the virus and has a mass of approximately 55 kDa. The E protein facilitates the attachment and fusion processes required for viral infection. This glycoprotein is highly expressed in host tissues where Japanese encephalitis virus or JEV infects and spreads especially in neural and endothelial cells.
Biological function summary
The E glycoprotein of Japanese encephalitis virus is essential for the viral lifecycle as it mediates host cell recognition and entry. It functions as a part of the viral envelope complex and interacts with host cell surface receptors to initiate infection. This protein undergoes conformational changes to fuse the viral membrane with that of the host. Its ability to recognize and bind receptors makes it an important element for viral propagation and pathogenicity.
Pathways
The Japanese encephalitis virus E glycoprotein is integral to the viral entry pathway in host cells. It is involved in the endocytosis and membrane fusion processes which are the first steps in the viral lifecycle. The E protein interacts with cellular proteins such as clathrin and ATPase in these pathways. Its role is important for the transition of the virus from the extracellular environment into the intracellular space where replication occurs.
The Japanese encephalitis virus E glycoprotein is directly linked to the pathogenesis of Japanese encephalitis a serious neurological disease caused by JEV infection. The E glycoprotein's interaction with host immunity influences disease severity and spread. Moreover it has connections with viral components like the JEV core protein which is involved in encapsidation and virion assembly. These associations highlight the significance of the E glycoprotein in both the viral life cycle and the development of disease making it a target for vaccine and antiviral strategies.