Abcam, ab42123, Anti-Zearalenone antibody [11C9]

Size: 100µL
Mouse Monoclonal Zearalenone antibody. Suitable for ELISA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Zearalenone.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:11C9,
Isotype:IgG1,
Light chain type:lambda,
Carrier free:No,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Zearalenone also known as F-2 toxin is a non-steroidal estrogenic mycotoxin produced by Fusarium fungi. It weighs 318.4 g/mol and commonly contaminates cereal crops such as maize wheat and barley. This compound mimics estrogen by binding to estrogen receptors in various tissues affecting hormonal balance. Its expression occurs mainly in agricultural environments where Fusarium fungi thrive.
Biological function summary
Zearalenone impacts reproductive systems in animals by competing with endogenous estrogens for receptor binding leading to disruptions in reproductive cycles and development. While not part of a specific protein complex Zearalenone's interaction with estrogen receptors allows it to interfere with normal hormonal signaling pathways. This interference can affect both estrogen-dependent gene expression and cellular functions in the exposed organism.
Pathways
Zearalenone effectively alters hormonal regulation and the signaling pathways involving estrogen receptors. It can significantly influence the endocrine axis particularly affecting the hypothalamic-pituitary-gonadal (HPG) axis which controls reproductive functions. Related to the estrogen signaling pathway proteins such as estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) play key roles in mediating Zearalenone's effects.
Zearalenone's estrogenic activity contributes to reproductive disorders such as infertility and early puberty particularly in livestock. Its interference with the HPG axis and estrogen receptors including ERα and ERβ can lead to pathological changes in reproductive hormone levels. Moreover exposure to Zearalenone has associations with an increased risk of estrogen-dependent cancers like breast cancer due to its persistence in disrupted hormonal environments over time.