Abcam, ab43055, Recombinant Treponema pallidum p47 protein

Size: 200µg
Recombinant Treponema pallidum p47 protein is a Treponema pallidum subsp. pallidum str. Nichols Fragment protein, expressed in Escherichia coli, with >90%, suitable for ELISA, WB.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P29723,
Animal free:No,
Carrier free:No,
Species:Treponema pallidum subsp. pallidum str. Nichols,
Storage buffer:pH: 8Constituents: 48% Urea, 0.158% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Treponema pallidum p47 protein also known as Tp47 functions as a protease integral to the bacterium Treponema pallidum which causes syphilis. It has a molecular mass of approximately 47 kDa. This protein expresses in the outer membrane of the bacterium playing a pivotal role in modulating host-pathogen interactions. Through its proteolytic activity Tp47 influences the bacterium's ability to evade the host's immune response facilitating chronic infection.
Biological function summary
Tp47 engages in processes assisting the bacterium to persist in its human host. This protein does not individually perform functions; it is a part of multi-protein complexes allowing the bacterium to interact with the human immune system. These interactions alter immune responses giving the bacterium a better chance of escaping detection or destruction by host defenses. Tp47's interactions with other proteins in these complexes set the stage for more varied effects on the host's physiological systems.
Pathways
Tp47 interacts with several key pathways in the host's immune system. These include the complement cascade pathway where Tp47's activity can impact the bacterium's chances of survival by interfering with complement-mediated lysis. Additionally researchers associate Tp47 with the oxidative burst process which plays a role in phagocytosis. Another protein TpN47 is related to the Tp47 activity through its role in these pathways assisting in masking the bacterium from immune cells.
Tp47 has a significant association with syphilis a chronic systemic infection. This protein's role in evading immune surveillance makes it a target for studying persistent treponemal infections. Additionally Tp47 connects to neurodegenerative pathways due to tertiary syphilis's potential impact on the nervous system. Understanding Tp47's interactions with proteins like TpN47 in these contexts can advance therapeutic strategies against sequelae of syphilis including neurological complications.