Abcam, ab43606, Anti-SGK1 antibody

Size: 100µg
Rabbit Polyclonal SGK1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 21 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Replenishment batches of our polyclonal antibody, ab43606 are tested in WB. Previous batches were additionally validated in ICC/IF. This application is still expected to work and is covered by our Abpromise guarantee. You may also be interested in our alternative recombinant antibody, ab32374.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Serum and Glucocorticoid-Regulated Kinase 1 also known as SGK1 is a protein kinase involved in cellular stress response. It consists of approximately 49 kDa and is encoded by the SGK1 gene. SGK1 is expressed in several tissues including the kidney pancreas and liver. It transfers phosphate groups from ATP to serine or threonine residues on target proteins functioning as an important regulator of ion channels enzymes and other cellular proteins.
Biological function summary
SGK1 regulates ion transport cell proliferation and survival pathways. SGK1 is not usually part of large protein complexes but interacts dynamically with other proteins to exert its effects. It plays a major role in regulating sodium channels in the kidney therefore modulating sodium balance and blood pressure. It also affects various cell survival mechanisms influencing cell growth and apoptosis in response to physiological cues.
Pathways
SGK1 is involved in the PI3K/AKT/mTOR signaling pathway and the WNK/SPAK pathway. These pathways influence cellular growth metabolism and ion transport. SGK1 shares pathway relevance with proteins like AKT1 and mTOR in the PI3K/AKT/mTOR axis impacting various metabolic and growth-related cellular processes. In the WNK/SPAK pathway SGK1 regulates ion channels in collaboration with WNK kinases affecting electrolyte balance.
SGK1 has implications in hypertension and cancer. Overactivity of SGK1 can lead to increased sodium retention resulting in hypertension. This connects SGK1 to diseases involving blood pressure regulation where it often interacts with the epithelial sodium channel (ENaC). In cancer SGK1 contributes to tumor progression by supporting cell survival with interactions alongside AKT1 frequently observed in cancerous pathways. Alterations in SGK1 levels or activity may therefore serve as a therapeutic target for managing these conditions.