Abcam, ab45074, Anti-CFP10 antibody

Size: 100µg
Rabbit Polyclonal ESXB antibody. Suitable for WB and reacts with Mycobacterium tuberculosis samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mycobacterium tuberculosis,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab45074 recognises native and E coli expressed recombinant CFP10.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purity: > 95% (by SDS-PAGE), Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CFP10 also known as ESAT-6-like protein 1 is a small secretory protein with a molecular weight of about 10.7 kDa. In Mycobacterium tuberculosis CFP10 forms a complex with ESAT-6 and both are important components of the ESX-1 secretion system. CFP10 is expressed primarily in pathogenic mycobacteria including Mycobacterium tuberculosis and Mycobacterium bovis. Its expression plays an important role in the infection process of these bacteria within host cells.
Biological function summary
Through interaction with ESAT-6 CFP10 is involved in the modulation of the host immune response. The CFP10-ESAT-6 complex contributes to the disruption of phagosomal membranes allowing the bacteria to escape into the cytosol of infected macrophages. This process helps the bacteria in evading the host immune system. The complex also influences the secretion of certain cytokines by the host impacting the immune regulatory mechanisms.
Pathways
The CFP10-ESAT-6 interaction plays a part in the ESX-1 secretion system pathway important for the virulence of Mycobacterium tuberculosis. This pathway is involved in modulating immune responses and enabling cellular invasion. The systems of ESX-1 are also connected to proteins like EspA and EspC whichs actively contribute to these mechanisms. Understanding the dynamics of these pathwaysrophic systems pathways is essential for developing tuberculosis treatments.
CFP10 has significant relevance to tuberculosis a disease caused by Mycobacterium tuberculosis. Its role in pathogenicity of the bacterium makes it a target for diagnostic and therapeutic strategies. Furthermore CFP10 is associated with latent tuberculosis infection where it acts as a virulence factor interacting with proteins like ESAT-6 to modulate the host's immune response. Effective targeting of the CFP10-ESAT-6 complex holds potential for new interventions against tuberculosis.