Abcam, ab45153, Recombinant Human JNK3 protein

Size: 20µg
Recombinant Human JNK3 protein is a Human Full Length protein, expressed in Escherichia coli, with >75%, suitable for WB.
Key facts
Purity:>75% Densitometry,
Expression system:Escherichia coli,
Tags:GST tag N-Terminus,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P53779,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0418% EGTA, 0.00292% EDTA, 0.00174% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JNK3 also known as c-Jun N-terminal kinase 3 belongs to the mitogen-activated protein kinase (MAPK) family. It has a molecular weight of approximately 48 kDa. This protein is part of the signaling cascade that responds to stress stimuli such as cytokines and ultraviolet irradiation. JNK3 expression occurs mainly in the brain but some reports note its expression in the heart and pancreas as well.
Biological function summary
JNK3 performs critical functions in neuronal apoptosis and neurodegeneration. JNK3 is part of the MAPK signaling complex which regulates various cellular activities including gene expression and cell differentiation. Activation of JNK3 leads to the phosphorylation and activation of transcription factors like c-Jun which assist in controlling stress-induced cellular responses.
Pathways
Queries into MAPK pathways reveal significant involvement of JNK3 in the stress-activated protein kinase (SAPK) pathway. JNK3 interacts with proteins such as ASK1 and MKK4/7 serving as upstream kinases to modulate environmental stress responses. The pathway also relates to other MAPKs like ERK and p38 although they perform distinct functions within the signaling network.
JNK3 has strong connections to neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Dysregulation in JNK3 signaling leads to increased neuronal cell death aggravating disease pathology. In Alzheimer's disease JNK3 may interact with tau protein contributing to tau phosphorylation and neurofibrillary tangle formation. In Parkinson's disease JNK3 involvement in dopaminergic neuron apoptosis highlights its potential role in disease progression linking it further to key proteins implicated in neurodegeneration.