Abcam, ab4527, Anti-TRIM4 antibody

Size: 100µg
Goat Polyclonal TRIM4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRIM4 aa 450 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRIM4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9C037,
Specificity:This antibody is expected to recognise both human isoforms.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM4 also known as tripartite motif-containing protein 4 is a protein that functions mechanically as an E3 ubiquitin-protein ligase. It facilitates the attachment of ubiquitin molecules onto specific substrate proteins marking them for proteasomal degradation. TRIM4 has a molecular mass of approximately 57 kDa. It is expressed in various tissues with notable expression in immune system-related tissues such as the spleen and lymph nodes.
Biological function summary
TRIM4 participates in the regulation of innate immune responses and antiviral defense. It is not known to be a component of large multi-protein complexes instead acting more autonomously. The protein helps in modulating the levels of interferon and other cytokines which are important for the body's antiviral response. Its ability to interact with signaling molecules like MAVS influences its role in immune regulation.
Pathways
TRIM4 plays an important role in the immune signaling cascade. It is involved in the RIG-I-like receptor signaling pathway where it helps amplify antiviral signaling in response to pathogen detection. The protein interacts with other molecules in the pathway including RIG-I and TBK1 to promote the production of antiviral cytokines. These interactions establish TRIM4's position as an important player in the maintenance of immune homeostasis during viral infections.
TRIM4 has associations with certain viral infections and autoimmune disorders. Altered regulation or expression of TRIM4 is linked to conditions characterized by dysregulation of immune responses such as systemic lupus erythematosus (SLE). The function of TRIM4 in these conditions can be modulated by interactions with proteins like IRF3 which are critical for the control of inflammatory responses. Understanding TRIM4's role can facilitate the development of therapeutic strategies in targeting immune-related diseases.