Abcam, ab47980, Anti-Alpha 1 microglobulin antibody

Size: 150µg
Rabbit Polyclonal Alpha 1 microglobulin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Full Length Protein corresponding to Human Protein AMBP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Human Protein AMBP. The exact immunogen used to generate this antibody is proprietary information.P02760

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha-1-microglobulin also known as alpha-1-microglycoprotein or A1M is a protein with a mass of approximately 26 kDa. It is mainly expressed in the liver and secreted into the blood plasma. Alpha-1-microglobulin can bind to small peptides and free radicals acting as a scavenger. It exists in a monomeric form and is present in various bodily fluids including urine and amniotic fluid.
Biological function summary
This protein serves as a protective factor against oxidative stress. Alpha-1-microglobulin is part of the lipocalin protein family which has roles in transport of small hydrophobic molecules in extracellular spaces. Its antioxidant properties help protect biological macromolecules from damage induced by oxidative agents. Alpha-1-microglobulin contains heme-binding sites which contribute to its protective biochemical actions.
Pathways
Alpha-1-microglobulin participates in oxidative stress-related and inflammatory pathways. Within the oxidative stress pathway it interacts with heme oxygenase and other heme-binding proteins to mitigate toxic effects of excess free heme. In inflammatory pathways it links with proteins such as albumin and immunoglobulin components which further supports immune response and cellular protection mechanisms.
Alpha-1-microglobulin has associations with conditions like preeclampsia and kidney disease. In preeclampsia its levels can indicate oxidative stress and placental dysfunction involving interactions with other proteins such as haptoglobin. In kidney disease altered levels of alpha-1-microglobulin in urine serve as a biomarker for tubular dysfunction connecting it to conditions affecting renal function and health.