Abcam, ab48508, Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1]

Size: 50µg
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (ab48508) is a mouse monoclonal antibody detecting 8-Hydroxy-2'-deoxyguanosine in IHC-P . - Over 140 publications - Trusted since 2007
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N45.1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:Yes,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (ab48508) is a mouse monoclonal antibody and is validated for use in IHC-P.
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (ab48508) has been cited over 145 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (ab48508) has high sensitivity and specificity.
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (ab48508) has 9 independent reviews from customers.
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1] (ab48508) specifically detects 8-Hydroxy-2'-deoxyguanosine (UniProt ID: ; Molecular weight: kDa) and is sold in 50 µg selling sizes.
This product was changed from ascites to tissue culture supernatant on 27th February 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
8-Hydroxy-2'-deoxyguanosine (8-OHdG) also known as 8-oxo-2'-deoxyguanosine is a well-known biomarker for oxidative DNA damage. This target forms when reactive oxygen species (ROS) affect DNA causing oxidation of the guanine base. Molecular mass of 8-OHdG is about 299 Daltons. 8-OHdG is found in various tissues due to its role as a marker for oxidative stress making it widespread in different cellular environments.
Biological function summary
Oxidative stress impacts DNA integrity and the formation of 8-OHdG indicates damage within the DNA. It does not form part of a larger complex but it results from the interacting effects of ROS on nucleic acids. The presence of 8-OHdG in DNA may also trigger repair processes to fix these oxidized lesions and maintain genomic stability.
Pathways
8-OHdG plays a significant role in pathways responsible for DNA damage response and repair. It involves the base excision repair (BER) pathway important for correcting oxidative lesions. Proteins such as OGG1 (8-oxoguanine glycosylase) recognize and excise 8-OHdG initiating further repair steps to protect genetic information.
Oxidative damage marked by 8-OHdG associates with cancer and neurodegenerative diseases like Alzheimer's. Elevated levels of 8-OHdG indicate increased oxidative stress a contributor to cancer progression. In Alzheimer's oxidative stress impacts neuronal survival. In these conditions proteins like OGG1 interact with 8-OHdG influencing disease development and progression by repairing oxidative DNA damage.