Abcam, ab48757, Recombinant Human Recoverin protein

Size: 50µg
Recombinant Human Recoverin protein is a Human Full Length protein, in the 1 to 200 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, WB.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P35243,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.242% Tris, 0.0292% EDTA, 0.019% Magnesium chloride

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Recoverin also known as RCVRN is a calcium-binding protein part of the neuronal calcium sensor family. With a molecular weight of approximately 23 kDa it is mainly found in the retina and pineal gland. It functions in the phototransduction process particularly in the recovery phase of visual responses. Recoverin interacts with other proteins in a calcium-dependent manner and plays a role in inhibiting rhodopsin kinase activity when calcium levels are high.
Biological function summary
Recoverin regulates the inhibition of rhodopsin phosphorylation in photoreceptor cells. It is not part of a complex but works closely with G-protein coupled receptors in the retina to modulate the recovery of photo responses following light exposure. Its ability to bind to calcium ions triggers conformational changes that allow it to carry out these critical functions.
Pathways
One can consider that recoverin plays a significant role in the visual cycle and the phototransduction cascade. In these pathways recoverin modulates rhodopsin kinase and other related proteins to ensure proper rod and cone cell recovery following light stimulation. Recoverin interacts with proteins such as transducin enabling efficient modulation of light signal transduction and termination.
Recoverin has associations with cancer-associated retinopathy and age-related macular degeneration. Cancer-associated retinopathy an autoimmune condition involves antibodies against recoverin affecting normal function and leading to vision loss. In these conditions proteins like rhodopsin and other phototransduction components are impacted through the disruption caused by anti-recoverin antibodies.