Abcam, ab5065, Anti-FANCC antibody

Size: 100µg
Rabbit Polyclonal FANCC antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FANCC aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FANCC aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q00597,
Specificity:Detects a band at 60kDa in Hela cell lysate corresponding to FANCC.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This affinity-purified antibody is directed against human FANCC protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification., Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FANCC also known as Fanconi Anemia Complementation Group C protein plays an important role in DNA repair. It has a molecular mass of approximately 63 kDa. Expressed in various tissues including bone marrow and blood FANCC interacts with other proteins to maintain genomic stability. The protein assists in correcting DNA interstrand crosslinks preventing damage that can lead to genetic disorders.
Biological function summary
The Fanconi Anemia Complementation Group C protein forms part of the Fanconi anemia (FA) protein complex. This complex participates in the repair of DNA damage and stabilization of the genome. Through its action FANCC cooperates with other FA proteins to activate the FA pathway which is essential for proper cellular response to DNA damage. By facilitating repair processes FANCC helps protect cells from mutation accumulation and chromosomal instability.
Pathways
Multiple processes integrate the role of FANCC within cellular repair mechanisms. The protein engages in the FA/BRCA pathway a critical route responsible for DNA damage repair. FANCC operates alongside proteins such as FANCD2 and BRCA2 within this pathway forming a coordinated response to preserve genomic integrity. It also participates in pathways that promote cell survival under genotoxic stress conditions.
FANCC is linked to two major health conditions. Mutations or dysfunctions in FANCC lead to Fanconi Anemia a rare genetic disorder characterized by bone marrow failure and cancer predisposition. Additionally FANCC also has associations with certain cancers where its role in DNA repair is compromised. Within these diseases proteins such as BRCA2 and other FA complex members act with FANCC highlighting its importance in maintaining cellular health and preventing disease development.