Abcam, ab50852, Anti-ANKRD11 antibody [2022C8a]

Size: 50µg
Mouse Monoclonal ANKRD11 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ANKRD11 aa 1450-1600.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2022C8a,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ANKRD11 aa 1450-1600. The exact immunogen used to generate this antibody is proprietary information.Q6UB99,
Specificity:This antibody reacts with ANKRD11.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Protein G purified from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (~95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: BSA, PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANKRD11 also known by alternate names such as ANKRD13 and KIAA0464 is a mechanistic protein that plays an important part in transcriptional regulation by acting as a co-repressor. The protein has a molecular mass of approximately 285 kDa and features ankyrin repeats which facilitate protein-protein interaction. ANKRD11 is expressed in various tissues with a significant presence in the brain suggesting its importance in neural functions.
Biological function summary
ANKRD11 influences several processes through its involvement in the regulation of gene expression. It is a member of the transcriptional regulatory complex where it interacts with other proteins to modify chromatin structure and influence transcription. ANKRD11 can modulate the activity of several transcription factors impacting cellular proliferation differentiation and other vital cellular functions.
Pathways
ANKRD11 plays a role in key signaling pathways such as the Wnt signaling pathway where it regulates gene expression important for cell fate determination. It interacts with proteins like beta-catenin pivotal in the transduction of Wnt signals. ANKRD11 is also linked with the p53 pathway which governs cell cycle control and apoptosis establishing interfaces with proteins involved in DNA damage response.
ANKRD11 mutations relate to KBG syndrome characterized by developmental delays and craniofacial anomalies. This syndrome showcases the involvement of ANKRD11 in neural development and structural formation. Additionally ANKRD11 dysregulation has been implicated in neurodevelopmental disorders and autism spectrum disorders where it might interact with proteins implicated in synaptic development and neural connectivity.