Abcam, ab50976, Anti-ABCF1 antibody [ABC5H06]

Size: 100µg
Mouse Monoclonal ABCF1 antibody ABC5H06. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:ABC5H06,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ABCF1. The exact immunogen used to generate this antibody is proprietary information.Q8NE71

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Concentrated and dialyzed culture medium (protein free medium) of hybridoma, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: 1.16% Sodium chloride, 1% BSA, 0.316% Tris HCl, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABCF1 also known as ATP-binding cassette sub-family F member 1 helps in cellular processes by facilitating the transport of various molecules across membranes. It weighs approximately 95 kDa. ABCF1 expression occurs in various tissues notably present in immune cells such as macrophages and monocytes. This protein does not function in drug transport and is an exception among ABC transporters because it lacks a transmembrane domain.
Biological function summary
ABCF1 plays a role in regulatory processes associated with immunity and inflammation. It acts as a critical component of the protein synthesis machinery influencing translation initiation. Although it does not form stable complexes it interacts transiently with ribosomal machinery. Its involvement in inflammation suggests it contributes to macrophage activation and innate immune responses.
Pathways
ABCF1 participates in inflammatory pathways and protein synthesis regulation. In the inflammatory pathway it engages in processes that modulate cytokine production. Also ABCF1 interfaces with proteins involved in translation like eukaryotic initiation factors regulating their activity during stress or immune response. These interactions make it a significant contributor to cellular protein homeostasis during inflammation.
ABCF1 connects to autoimmune conditions like rheumatoid arthritis. Increased expression in certain conditions implies its role in chronic inflammation. ABCF1 also interacts with TNF-alpha a cytokine heavily involved in inflammatory diseases suggesting its involvement in exacerbating inflammatory processes. Understanding ABCF1's regulatory mechanisms may aid in developing therapeutic interventions targeting inflammatory diseases.