Abcam, ab50991, Anti-BTG1 antibody [2095C1a]

Size: 100µg
Mouse Monoclonal BTG1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2095C1a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab50991 has not yet been tested on endogenous protein in cell lysate.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTG1 also known as B-cell translocation gene 1 protein is a member of the BTG/TOB family. This protein generally serves a role in cell cycle regulation by acting as an antiproliferative agent. BTG1 has an approximate mass of 22 kDa. Its expression is mainly found in the hematopoietic system with notable presence in the lymphoid tissues suggesting a significant role in immune system functionality.
Biological function summary
BTG1 affects fundamental cellular processes through its interaction with other proteins. This protein plays a role in cell cycle regulation by influencing key processes like proliferation differentiation and apoptosis. BTG1 functions as part of a complex that involves interactions with CCR4-NOT transcription complex and various growth regulators. These engagements highlight the multifaceted roles of BTG1 in cell regulation.
Pathways
BTG1 plays an important role in the regulation of cellular growth and differentiation pathways. It interfaces with key players such as cyclin D1 and p53 both important for cell cycle progression and DNA damage response pathways. These interactions position BTG1 within the broader regulatory network of cell cycle control maintaining cellular growth homeostasis and preventing unregulated proliferation.
BTG1 involvement has been observed in certain types of cancer particularly leukemia. Its expression levels can indicate the progression or prognosis of such malignancies. BTG1 often shows altered expression levels in conjunction with proteins like B-cell lymphoma 2 (Bcl-2) in the context of hematological disorders. Understanding BTG1 interactions provides valuable insight into potential therapeutic targets for managing these diseases.